Correctional inmates and staff are at increased risk for TB infection

In the United States, tuberculosis screening in correctional settings is a public health priority. Incarcerated populations have a higher likelihood of carrying risk factors for TB, including (1):

• HIV co-infection     • Homelessness     • Substance abuse     • Alcohol abuse

The best way to prevent TB in correctional facilities is to identify latent TB infection and treat it before it poses a threat.

Streamline TB testing with QuantiFERON-TB Gold Plus

QuantiFERON-TB Gold testing was introduced in New York City jails in 2011, replacing tuberculin skin testing (TST) which had been associated with substantial incomplete screening rates. In a published study of 35,090 persons, Katyal et al. reported that QFT testing in NYC jails yielded 6.3% positive, 93.4% negative, and 0.2% indeterminate results – and concluded that IGRA-based testing should be recommended in correctional settings (2).

In a separate 2016 study of 351 subjects tested with both QFT and the TB skin test at a Texas jail, Nijhawan et al. reported that the cost per LTBI case detected was nearly three times higher for TST than QFT-GIT ($1247 v $460; 3).

We found a substantially higher rate of QFT-GIT positivity compared to TST…  QFT-GIT as an initial screening tool was more time-efficient, and had four-fold fewer labor costs.


Want to learn more about testing with QuantiFERON-TB Gold Plus?

Contact a QFT-Plus expert

Modernize staff and inmate screening with QFT-Plus

Accurate

  • Unaffected by prior BCG vaccination
  • >97% specificity, >94% sensitivity

Convenient

  • Single patient visit
  • Single tube collection option

Cost-effective

  • Improves screening efficiency and reduces program costs (3)

Find out more about QFT-Plus at our Provider Resources Portal

References

1. CDC. Tuberculosis in the United States, 2016. https://www.cdc.gov/tb/statistics/reports/2016/pdfs/2016_Surveillance_FullReport.pdf
2. Katyal et al., 2018; IGRA-Based Screening for Latent Tuberculosis Infection in Persons Newly Incarcerated in New York City Jails. Journal of Correctional Healthcare.
3. Nijhawan, A., et al. (2016) Cost analysis of tuberculin skin test and the QuantiFERON-TB Gold In-tube test for tuberculosis screening in a correctional setting in Dallas, Texas, USA. BMC Infect. Dis. 16, 564

Disclaimer: The performance of the USA format of the QFT-Plus test has not been extensively evaluated with specimens from individuals who have impaired or altered immune functions, such as those who have HIV infection or AIDS, those who have transplantation managed with immunosuppressive treatment or others who receive immunosuppressive drugs (e.g., corticosteroids, methotrexate, azathioprine, cancer chemotherapy), those who have other clinical conditions, such as diabetes, silicosis, chronic renal failure, and hematological disorders (e.g., leukemia and lymphomas), or those with other specific malignancies (e.g., carcinoma of the head or neck and lung).

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